Research Team: Nutrigenomics Team
Place of Work: Institute of Animal Reproduction and Food Research, Olsztyn
Keywords: Transcriptomics, ATAC-seq, Mechanistic modeling, Human Intervention, Vitamin D, Multi-omics, Nutrigenomics
Research focus:
My research explores how vitamin D influences the healthy human immune system. I work with data from human intervention trials such as VitDHiD and VitDPAS, where I classify individuals into high, mid, and low responders based on transcriptomic and ATAC-seq profiles. This approach helps me understand inter-individual variability in response to supplementation at a molecular level. Using multi-omics integration and statistical modeling, I aim to uncover consistent patterns in immune regulation driven by vitamin D. My broader goal is to build a mechanistic model that explains how vitamin D modulates immune function in diverse individuals. By the end of my PhD, I hope to offer insights that bridge personalized nutrition and systems immunology, ultimately contributing to precision health strategies.
Publications:
Ghosh Dastidar, R., Jaroslawska, J., Malinen, M. et al. In vivo vitamin D targets reveal the upregulation of focal adhesion- related genes in primary immune cells of healthy individuals. Sci Rep 14, 17552 (2024). https://doi.org/10.1038/s41598- 024-68741-9
Jaroslawska J, Ghosh Dastidar R, Carlberg C (2024) In vivo vitamin D target genes interconnect key signaling pathways of innate immunity. PLOS ONE 19(7): e0306426. https://doi.org/10.1371/journal.po ne.0306426
AlGhamdi A, S., Ghosh Dastidar, R., et al. Evaluation of the vitamin D response index in a Saudi cohort. Saudi PharmaceuticalJournal, 102137(2024).https://doi.org/10.1016/j.jsps.2024.102137
Gospodarska E, Ghosh Dastidar R, Carlberg C. Intervention Approaches in Studying the Response to Vitamin D3 Supplementation. Nutrients. 2023; 15(15):3382. https://doi.org/10.3390/nu15153382
Gospodarska, E., Dastidar, R.G., Jaroslawska, J. et al. Transcriptomic profiling of immune modulation induced by vitamin D3 in the VitDPAS and VitDHiD cohort studies. Sci Rep 15, 17334 (2025). https://doi.org/10.1038/s41598-025-02495-w
Conferences and seminar:
POSTER: Poster presented on “Vitamin D response index of healthy Saudis” on 6th September 2023 at NuGOweek 2023, Senigallia
TALK: Talk presentation on “Extension of the concept of the vitamin D response index based on cohorts from Saudi Arabia” on 23rd September 2023 at EVIDAS 2023, Warsaw.
TRAINING PROGRAMME: Attended the NuGO post-graduate course 2023 on “Primers in omic data analysis: genomics and transcriptomics to boost your research in molecular nutrition” in Senigallia, Italy from 3rd-5th September 2023.
DISSEMINATION OF KNOWLEDGE: Participated in the annual PIKNIK NAUKOWY WARSZAWA 2023.
TALK: Talk presentation on “Vitamin D-Mediated Modulation of Innate Immunity in Healthy Individuals: Insights from an In vivoStudy” at the 5th European Summer School on Nutrigenomics, June 18-21, 2024
POSTER: Poster presented on “Transcriptome-Wide Analysis Reveals Interindividual Variability in Vitamin D Responsiveness” on 4thSeptember 2024 at NuGOweek 2024, Ghent, Belgium
TALK: Talk on „Unraveling the Power of Vitamin D Mechanistically: How Long-Term Supplementation Shapes Immune Health”, at NuGOweek 2025, September 2025 in Dublin, Ireland.
